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Experiment ID
142, 143, 144, 145, 147, 151, 161, 162, 163, 164, 168, 169, 170, 172
Pathogen
Escherichia coli
Contains Preferred Model
0
Reference
Immune response, ciprofloxacin activity, and gender differences after human experimental challenge by two strains of enterotoxigenic Escherichia coli
Host type
human
# of Doses
19.00
Μodel
beta-Poisson
a
7.54E-02
N50
1.7E+06
LD50/ID50
1.7E+06
Dose Units
CFU
Response
diarrhea
Agent Strain
ETEC B7A
Exposure Route
oral (with NaHCO3)
Experiment Dataset
Description: 
EPEC disease in the human model data
Dose Diarrhea No diarrhea Total
1E+06 3 3 6
1E+07 6 9 15
1E+08 6 1 7
1E+08 7 4 11
1E+08 7 5 12
1E+08 9 3 12
1E+08 6 3 9
1E+08 4 2 6
1E+08 3 1 4
1E+08 4 0 4
2.7E+08 9 7 16
5E+08 19 8 27
1E+09 5 3 8
1E+09 7 1 8
1E+09 5 5 10
1E+10 8 0 8
1E+10 5 4 9
1E+10 9 3 12
1E+10 9 5 14

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value		 χ20.95,m-k 
p-value
Exponential 412 393 18 3.84 
0		 28.9 
0
Beta Poisson 19.1 17 27.6 
0.322
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 7.54E-02 8.28E-03 1.11E-02 1.51E-02 1.46E-01 1.59E-01 1.84E-01
N50 1.7E+06 2.80E-11 1.91E-06 1.44E-03 2.34E+07 3.09E+07 4.67E+07

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

beta Poisson model plot, with confidence bounds around optimized model