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Experiment ID
250
Pathogen
Prion
Agent Strain
scrapie strain 263k
Contains Preferred Model
Yes
Reference
Jacquemot, C. ., Cuche, C. ., Dormont, D. ., & Lazarini, F. . (2005). High Incidence of Scrapie Induced by Repeated Injections of Subinfectious Prion Doses. Journal of Virology, 79(14). https://doi.org/10.1128/JVI.79.14.8904-8908.2005
Exposure Route
oral
Response
death
Host type
hamsters
# of Doses
5.00
Dose Units
LD50 i.c.
Μodel
beta-Poisson
a
1.76E+00
N50
1.04E+05
LD50/ID50
1.04E+05
Description
hamsters/scrapie strain 263K model data 
Dose Dead Survived Total
200 0 40 40
2000 1 79 80
2E+04 9 71 80
2E+05 58 22 80
2E+06 29 1 30

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 14.5 12.6 4 3.84 
0.000382 		9.49 
0.00576
Beta Poisson 1.92 3 7.81 
0.589
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 1.76E+00 7.48E-01 8.76E-01 9.66E-01 1.44E+04 1.73E+04 2.08E+04
N50 1.04E+05 7.05E+04 7.83E+04 8.22E+04 1.34E+05 1.40E+05 1.55E+05

 

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

beta Poisson model plot, with confidence bounds around optimized model

References

  • Diringer, H. ., Roehmel, J. ., & Beekes, M. . (1998). Effect of repeated oral infection of hamsters with scrapie. Journal of General Virology, 79. Retrieved from http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.541.3587&rep=rep1&type=pdf