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Experiment ID
283,284
Pathogen
Pseudomonas aeruginosa
Contains Preferred Model
0
Reference
Age-Related Susceptibility to Pseudomonas aeruginosa Ocular Infections in Mice
Host type
Swiss webster mice(10day old)
# of Doses
12.00
Μodel
beta-Poisson
a
6.01E-01
N50
1.48E+04
LD50/ID50
1.48E+04
Dose Units
CFU
Response
death
Agent Strain
ATCC 19660
Exposure Route
injected in eyelids
Experiment Dataset
Description: 
mice (10day old, day1-21) /  Pseudomonas aeruginosa [1]
Dose Dead Survived Total
2.5 0 10 10
2.5 0 10 10
25 0 16 16
25 0 16 16
250 0 15 15
250 0 15 15
2500 0 13 13
2500 2 11 13
25000 12 4 16
25000 13 3 16
250000 14 3 17
250000 14 3 17

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value		 χ20.95,m-k 
p-value
Exponential

48.6 

 36.3 11 3.84 
 1.65e-09		 19.7
1.09e-06
Beta Poisson

12.3

 10 18.3 
0.265
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 500 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 6.01E-01 3.11E-01 3.69E-01 3.97E-01 1.04E+00 1.20E+00 2.01E+00
N50 1.48E+04 8.01E+03 9.07E+03 1.00E+04 2.29E+04 2.55E+04 2.83E+04

 

 

 

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

beta Poisson model plot, with confidence bounds around optimized model

References

  1. Hazlett, L. D., Rosen D. D., & Berk R. S. (1978).  Age-Related Susceptibility to Pseudomonas aeruginosa Ocular Infections in Mice. Infection and Immunity. 20, 1.