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Experiment ID
283,284
Pathogen
Pseudomonas aeruginosa
Agent Strain
ATCC 19660
Contains Preferred Model
No
Reference
Hazlett, L. D., Rosen, D. D., & Berk, R. S. (1978). Age-Related Susceptibility to Pseudomonas aeruginosa Ocular Infections in Mice. Infection and Immunity, 20, 1.
Exposure Route
injected in eyelids
Response
death
Host type
Swiss webster mice(10day old)
# of Doses
12.00
Dose Units
CFU
Μodel
beta-Poisson
a
6.01E-01
N50
1.48E+04
LD50/ID50
1.48E+04
Description
mice (10day old, day1-21) /  Pseudomonas aeruginosa 
Dose Dead Survived Total
2.5 0 10 10
2.5 0 10 10
25 0 16 16
25 0 16 16
250 0 15 15
250 0 15 15
2500 0 13 13
2500 2 11 13
25000 12 4 16
25000 13 3 16
250000 14 3 17
250000 14 3 17

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential

48.6 

 36.3 11 3.84 
 1.65e-09 		19.7
1.09e-06
Beta Poisson

12.3

 10 18.3 
0.265
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 500 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 6.01E-01 3.11E-01 3.69E-01 3.97E-01 1.04E+00 1.20E+00 2.01E+00
N50 1.48E+04 8.01E+03 9.07E+03 1.00E+04 2.29E+04 2.55E+04 2.83E+04

 

 

 

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

beta Poisson model plot, with confidence bounds around optimized model

References

  • Hazlett, L. D., Rosen, D. D., & Berk, R. S. (1978). Age-Related Susceptibility to Pseudomonas aeruginosa Ocular Infections in Mice. Infection and Immunity, 20, 1.