General Overview
Rhinovirus, a small icosahedral viruses made of a protein capsid that encases a singlestranded, positivesense RNA molecule, belongs to the Picornaviridae family. About 100 different serotypes have been identified and characterized by their own specific antigens.
Rhinoviruses are responsible for 30 to 50% of adult colds and 10 to 25% of colds in children. Other coldcausing viruses are adenoviruses, coronaviruses, coxsackieviruses, echoviruses, orthomyxoviruses, paramyxoviruses, respiratory syncytial virus, and enteroviruses, each of which produces infections with slightly different patterns of symptoms and severity. Several of the abovementioned viruses also account for other more severe illnesses, according to Bella and Rossmann^{[1]}.
Summary Data
Hendley et al. (1972)^{[2]} inoculated young adult human volunteers over the age of 21 with Rhinovirus type 39 (RV 39), strain SF 299, and rhinovirus type 14 (RV 14), strain SF 765, via intranasal exposure route. Shedding of the challenge virus and/or a fourfold or greater increase in titer of serum antibody to a homotypic rhinovirus were accepted as evidence of infection.
Summary
The responses caused by doses less than one observed in these two experiments are probably due to the uncertainties of dose counting in the original study.
References
 Bella, J.., & Rossmann M.. G. (1999). Rhinoviruses and their ICAM receptors. Journal of structural biology. 128, 69–74.
 Hendley, J. O., Edmondson W. P., & Gwaltney J. M. (1972). Relation between Naturally Acquired Immunity and Infectivity of Two Rhinoviruses in Volunteers. Journal of Infectious Diseases. 125, 3.
ID  Exposure Route  # of Doses  Agent Strain  Dose Units  Host type  Μodel  LD50/ID50  Optimized parameters  Response type  Reference 

310  intranasal  6  type 14  TCID50  human  betaPoisson  3.83E+00 
α = 2.52E01 N_{50} = 3.83E+00 
infection  Relation between Naturally Acquired Immunity and Infectivity of Two Rhinoviruses in Volunteers." Journal of Infectious Diseases. 125 (1972): 3.  "
311  intranasal  6  type 39  TCID50  human  betaPoisson  1.9E01 
α = 7.01E01 N_{50} = 1.9E01 
infection  Relation between Naturally Acquired Immunity and Infectivity of Two Rhinoviruses in Volunteers." Journal of Infectious Diseases. 125 (1972): 3.  "
312  intranasal  6  type 14  TCID50  human  betaPoisson  2.22E+01 
α = 1.81E01 N_{50} = 2.22E+01 
infection  Relation between Naturally Acquired Immunity and Infectivity of Two Rhinoviruses in Volunteers." Journal of Infectious Diseases. 125 (1972): 3.  "
312, 313  intranasal  12  type 14  TCID50  human  betaPoisson  1.38E+01 
α = 1.82E01 N_{50} = 1.38E+01 
infection  Relation between Naturally Acquired Immunity and Infectivity of Two Rhinoviruses in Volunteers." Journal of Infectious Diseases. 125 (1972): 3.  "
313  intranasal  6  type 39  TCID50  human  betaPoisson  1.05E+01 
α = 2,00E01 N_{50} = 1.05E+01 
infection  Relation between Naturally Acquired Immunity and Infectivity of Two Rhinoviruses in Volunteers." Journal of Infectious Diseases. 125 (1972): 3.  "
64  intranasal  6  type 14  TCID50  human  betaPoisson  9.22E+00 
α = 2.01E01 N_{50} = 9.22E+00 
infection  Relation between Naturally Acquired Immunity and Infectivity of Two Rhinoviruses in Volunteers." Journal of Infectious Diseases. 125 (1972): 3.  "
65  intranasal  6  type 39  TCID50  human  betaPoisson  1.81E+00 
α = 2.21E01 N_{50} = 1.81E+00 
infection  Relation between Naturally Acquired Immunity and Infectivity of Two Rhinoviruses in Volunteers." Journal of Infectious Diseases. 125 (1972): 3.  "
LD_{50}/ID_{50} = 3.83E+00
N_{50} = 3.83E+00



Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.
beta Poisson model plot, with confidence bounds around optimized model
References
 J Hendley, O., Jr W. P. Edmondso, & Jr J. M. Gwaltney (1972). Relation between naturally acquired immunity and infectivity of two rhinoviruses in volunteers. Journal of Infectious Diseases. 125, 243–248.
LD_{50}/ID_{50} = 1.9E01
N_{50} = 1.9E01
Optimization Output for experiment 311



Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.
beta Poisson model plot, with confidence bounds around optimized model
References
 J Hendley, O., Jr W. P. Edmondso, & Jr J. M. Gwaltney (1972). Relation between naturally acquired immunity and infectivity of two rhinoviruses in volunteers. Journal of Infectious Diseases. 125, 243–248.
LD_{50}/ID_{50} = 2.22E+01
N_{50} = 2.22E+01



Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.
beta Poisson model plot, with confidence bounds around optimized model
References
 J Hendley, O., Jr W. P. Edmondso, & Jr J. M. Gwaltney (1972). Relation between naturally acquired immunity and infectivity of two rhinoviruses in volunteers. Journal of Infectious Diseases. 125, 243–248.
LD_{50}/ID_{50} = 1.38E+01
N_{50} = 1.38E+01

"

"

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.
beta Poisson model plot, with confidence bounds around optimized model
References
 J Hendley, O., Jr W. P. Edmondso, & Jr J. M. Gwaltney (1972). Relation between naturally acquired immunity and infectivity of two rhinoviruses in volunteers. Journal of Infectious Diseases. 125, 243–248.
LD_{50}/ID_{50} = 1.05E+01
N_{50} = 1.05E+01



Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.
beta Poisson model plot, with confidence bounds around optimized model
References
 J Hendley, O., Jr W. P. Edmondso, & Jr J. M. Gwaltney (1972). Relation between naturally acquired immunity and infectivity of two rhinoviruses in volunteers. Journal of Infectious Diseases. 125, 243–248.
LD_{50}/ID_{50} = 9.22E+00
N_{50} = 9.22E+00



Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.
beta Poisson model plot, with confidence bounds around optimized model
References
 J Hendley, O., Jr W. P. Edmondso, & Jr J. M. Gwaltney (1972). Relation between naturally acquired immunity and infectivity of two rhinoviruses in volunteers. Journal of Infectious Diseases. 125, 243–248.
LD_{50}/ID_{50} = 1.81E+00
N_{50} = 1.81E+00



Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.
beta Poisson model plot, with confidence bounds around optimized model
References
 J Hendley, O., Jr W. P. Edmondso, & Jr J. M. Gwaltney (1972). Relation between naturally acquired immunity and infectivity of two rhinoviruses in volunteers. Journal of Infectious Diseases. 125, 243–248.