Description
myco
 
Host
Male golden Syrian hamsters/12 weeks
# of Doses
3.00
Μodel
beta-Poisson
N50
7.93E+8
LD50/ID50
7.93E+8
Dose Units
CFU
Response
Liver infection
Exposure Route
Intratracheal inoculation
Contains Preferred Model
Status
fitted
a
0.048
Agent Strain
MAC serotype 8 (Human-derived, AIDS Patient)
Experiment ID
myco_intratracheal_2
Host type
hamsters
Experiment Dataset
Description
myco
Host
Male golden Syrian hamsters/12 weeks
# of Doses
3.00
Μodel
beta-Poisson
N50
1.42E+8
LD50/ID50
1.42E+8
Dose Units
CFU
Response
Disseminated infection
Exposure Route
Intratracheal inoculation
Contains Preferred Model
Status
fitted
a
0.201
k
4.87E-9
Agent Strain
MAC serotype 8 (Human-derived, AIDS Patient)
Experiment ID
myco_intratracheal
Host type
hamsters
Experiment Dataset
Description
hamsters/scrapie strain 263K model data 
Dose Dead Survived Total
200 0 40 40
2000 1 79 80
2E+04 9 71 80
2E+05 58 22 80
2E+06 29 1 30

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 14.5 12.6 4 3.84 
0.000382 		9.49 
0.00576
Beta Poisson 1.92 3 7.81 
0.589
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 1.76E+00 7.48E-01 8.76E-01 9.66E-01 1.44E+04 1.73E+04 2.08E+04
N50 1.04E+05 7.05E+04 7.83E+04 8.22E+04 1.34E+05 1.40E+05 1.55E+05

 

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

beta Poisson model plot, with confidence bounds around optimized model

# of Doses
5.00
Μodel
beta-Poisson
N50
1.04E+05
LD50/ID50
1.04E+05
Dose Units
LD50 i.c.
Response
death
Exposure Route
oral
Contains Preferred Model
a
1.76E+00
Agent Strain
scrapie strain 263k
Experiment ID
250
Host type
hamsters
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