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Experiment ID
238
Pathogen
Salmonella meleagridis
Contains Preferred Model
1
Reference
Experimental Human Salmonellosis: I. Pathogenicity of Strains of Salmonella Meleagridis and Salmonella Anatum Obtained from Spray-Dried Whole Egg
Host type
human
# of Doses
11.00
Μodel
beta-Poisson
a
3.89E-01
N50
1.68E+04
LD50/ID50
1.68E+04
Dose Units
CFU
Response
infection
Agent Strain
strain I
Exposure Route
oral (with eggnog)
Experiment Dataset
Description: 
Human / S. meleagridis strain I data [1]
Dose Infected Non-infected Total
12000 3 3 6
24000 4 2 6
52000 3 3 6
96000 3 3 6
155000 5 1 6
3E+05 6 0 6
720000 4 1 5
1150000 6 0 6
5.5E+06 5 1 6
2.4E+07 5 0 5
5E+07 6 0 6

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value		 χ20.95,m-k 
p-value
Exponential 71.8 63.8 10 3.84 
1.33e-15		 18.3 
1.98e-11
Beta Poisson 7.99 9 16.9 
0.535
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 3.89E-01 1.23E-01 1.74E-01 2.01E-01 1.12E+00 1.91E+00 3.82E+02
N50 1.68E+04 7.98E+01 1.08E+03 2.27E+03 4.78E+04 5.71E+04 7.49E+04

 

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

beta Poisson model plot, with confidence bounds around optimized model

References

  1. McCullough, NB., & Elsele CW. (1951).  Experimental human salmonellosis: I. Pathogenicity of strains of Salmonella meleagridis and Salmonella anatum obtained from spray-dried whole egg. Oxford Journal of Infectious Diseases. 88(3),