Submitted by admin on

Experiment ID
3
Pathogen
Yersinia pestis
Agent Strain
CO92
Contains Preferred Model
No
Reference
Rogers, J. . , V, Choi, Y. W., Giannunzio, L. F., Sabourin, P. J., Bornman, D. M., Blosser, E. G., & Clk, S. . (2007). Transcriptional responses in spleens from mice exposed to Yersinia pestis CO92. Microbial Pathogenesis, 43, 2. https://doi.org/10.1016/j.micpath.2007.04.001
Exposure Route
intraperitoneal
Response
death
Host type
mice
# of Doses
5.00
Dose Units
CFU
Μodel
exponential
k
3.45E-02
LD50/ID50
2.01E+01
Description
Mouse/ CO92 model data 
Dose Dead Survived Total
2 0 20 20
8 5 15 20
26 13 7 20
74 9 1 10
257 10 0 10

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 3.12 -9.43e-05 4 3.84 
1 		9.49 
0.539
Beta Poisson 3.12 3 7.81 
0.374
Exponential is preferred to beta-Poisson; cannot reject good fit for exponential.

 

Optimized k parameter for the exponential model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
k 3.45E-02 2.01E-02 2.28E-02 2.44E-02 4.89E-02 5.18E-02 5.79E-02
ID50/LD50/ETC* 2.01E+01 1.20E+01 1.34E+01 1.42E+01 2.84E+01 3.04E+01 3.44E+01
*Not a parameter of the exponential model; however, it facilitates comparison with other models.

 

Parameter histogram for exponential model (uncertainty of the parameter)

Exponential model plot, with confidence bounds around optimized model

References

  • Rogers, J. . , V, Choi, Y. W., Giannunzio, L. F., Sabourin, P. J., Bornman, D. M., Blosser, E. G., & Clk, S. . (2007). Transcriptional responses in spleens from mice exposed to Yersinia pestis CO92. Microbial Pathogenesis, 43, 2. https://doi.org/10.1016/j.micpath.2007.04.001