Description

Please Note

The results from this experiment are not recommended for use, rather they are present for reference purposes. The confidence intervals are not complete for this experiment since the data is not allowing for a stable bootstrap outcome. It is recommended to use the recommended model as this data is likely just capable of passing the test of trend, but still likely suboptimal for dose response modeling purposes.

 

Human Inaba Strain 569B 
Dose Diarrhea or culture positive No diarrhea or culture positive Total
1E+04 0 2 2
1E+06 0 4 4
1E+07 0 4 4
1E+08 2 2 4
1E+09 1 1 2
1E+10 0 1 1
1E+11 2 0 2

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom
χ20.95,1 
p-value
χ20.95,m-k 
p-value
Exponential 15.1 10.4 6 3.84 
0.00126
12.6 
0.0193
Beta Poisson 4.72 5 11.1 
0.451
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 1.98E-01 9.92E-04 9.92E-04 1.04E-03 3.20E-01 3.65E-01 4.07E-01
N50 6.36E+08 8.26E+05 8.26E+05 1.18E+08 5.33E+207 5.33E+207 8.87E+254

 

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

beta Poisson model plot, with confidence bounds around optimized model

# of Doses
7.00
Μodel
N50
6.36E+08
LD50/ID50
6.36E+08
Dose Units
Exposure Route
Contains Preferred Model
a
1.98E-01
Agent Strain
Inaba 569B
Experiment ID
35
Host type