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Experiment ID
62
Pathogen
Enterovirus
Agent Strain
porcine, PE3-ECPO-6
Contains Preferred Model
No
Reference
Cliver, D. O. (1981). Experimental infection by waterborne enteroviruses. Journal of Food Protection, 44, 861–865. Retrieved from http://www.jfoodprotection.org/doi/abs/10.4315/0362-028X-44.11.861?code=fopr-site
Exposure Route
oral
Response
infection
Host type
pig
# of Doses
3.00
Dose Units
PFU
Μodel
exponential
k
2.96E-04
LD50/ID50
2.34E+03
Description
Pigs/ Porcine enterovirus type 3 Strain model data 
Dose infected Non-infected Total
100 0 3 3
250 0 6 6
1000 2 4 6

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 1.24 -0.000314 2 3.84 
1 		5.99 
0.537
Beta Poisson 1.24 1 3.84 
0.265
Exponential is preferred to beta-Poisson; cannot reject good fit for exponential.

 

Optimized k parameter for the exponential model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
k 2.96E-04 2.40E-17 2.40E-17 2.40E-17 7.19E-04 7.19E-04 1.02E-03
ID50/LD50/ETC* 2.34E+03 6.77E+02 9.64E+02 9.64E+02 2.89E+16 2.89E+16 2.89E+16
*Not a parameter of the exponential model; however, it facilitates comparison with other models.

 

Parameter histogram for exponential model (uncertainty of the parameter)

Exponential model plot, with confidence bounds around optimized model

References

  • Cliver, D. O. (1981). Experimental infection by waterborne enteroviruses. Journal of Food Protection, 44, 861-865. Retrieved from http://www.jfoodprotection.org/doi/abs/10.4315/0362-028X-44.11.861?code=fopr-site