Description
 
Host
Pig/ 8-10 weeks old
# of Doses
15.00
Μodel
exponential
LD50/ID50
4.19E+7
Dose Units
CFU
Response
Lesions or culture in lymph nodes
Exposure Route
intravenous
Contains Preferred Model
Status
fitted
k
1.65E-8
Experiment ID
myco_intravenous_4
Host type
pig
Description
Host
Pig/ 8-10 weeks old
# of Doses
15.00
Μodel
exponential
LD50/ID50
8.79E+6
Dose Units
CFU
Response
Lesions or culture in lymph nodes
Exposure Route
intravenous
Contains Preferred Model
Status
fitted
k
7.88E-8
Agent Strain
M. avium serotype II strain SSC 1323 (porcine-derived)
Experiment ID
myco_intravenous_3
Host type
pig
Description
myco_3.png
Host
Pig/ 8-10 weeks old
# of Doses
15.00
Μodel
exponential
LD50/ID50
7.49E+7
Dose Units
CFU
Response
Lesions or culture in lymph nodes
Exposure Route
intravenous
Contains Preferred Model
Status
fitted
k
9.26E-9
Agent Strain
M. avium serotype II strain SSC 1323 (porcine-derived
Experiment ID
myco_intravenous_3
Host type
pig
Experiment Dataset
Description
Model data for rotavirus (OSU (ATCC VR892)) in the pig 
Dose Infected Non-infected Total
0.9 0 3 3
9 0 3 3
90 5 1 6
900 3 0 3
2800 2 0 2
9000 3 0 3
56000 2 0 2
1.1E+07 2 0 2
2.2E+08 2 0 2
4.5E+09 2 0 2

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 1.1 -0.0019 9 3.84 
1 		16.9 
0.999
Beta Poisson 1.1 8 15.5 
0.998
Exponential is preferred to beta-Poisson; cannot reject good fit for exponential.

 

Optimized k parameter for the exponential model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
k 1.73E-02 4.64E-03 7.21E-03 7.21E-03 3.28E-02 3.28E-02 3.28E-02
ID50/LD50/ETC* 4E+01 2.11E+01 2.11E+01 2.11E+01 9.61E+01 9.61E+01 1.49E+02
*Not a parameter of the exponential model; however, it facilitates comparison with other models.

 

Parameter histogram for exponential model (uncertainty of the parameter)

Exponential model plot, with confidence bounds around optimized model

# of Doses
10.00
Μodel
exponential
LD50/ID50
4E+01
Dose Units
particles
Response
infection
Exposure Route
intragastric
Contains Preferred Model
k
1.73E-02
Agent Strain
OSU (ATCC VR892)
Experiment ID
68
Host type
pig
Description
pigs/ Porcine enterovirus type 7 
Dose infected Non-infected Total
250 4 2 6
250 3 3 6
1000 5 0 5

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 0.614 -5.49e-05 2 3.84 
1 		5.99 
0.736
Beta Poisson 0.614 1 3.84 
0.433
Exponential is preferred to beta-Poisson; cannot reject good fit for exponential.

 

Optimized k parameter for the exponential model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
k 3.74E-03 1.83E-03 2.19E-03 2.19E-03 5.62E-03 5.62E-03 5.62E-03
ID50/LD50/ETC* 1.85E+02 1.23E+02 1.23E+02 1.23E+02 3.16E+02 3.16E+02 3.79E+02
*Not a parameter of the exponential model; however, it facilitates comparison with other models.

 

Parameter histogram for exponential model (uncertainty of the parameter)

Exponential model plot, with confidence bounds around optimized model

# of Doses
3.00
Μodel
exponential
LD50/ID50
1.85E+02
Dose Units
PFU
Response
infection
Exposure Route
oral
Contains Preferred Model
k
3.74E-03
Agent Strain
porcine, PE7-05i
Experiment ID
63
Host type
pig
Description
Pigs/ Porcine enterovirus type 3 Strain model data 
Dose infected Non-infected Total
100 0 3 3
250 0 6 6
1000 2 4 6

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 1.24 -0.000314 2 3.84 
1 		5.99 
0.537
Beta Poisson 1.24 1 3.84 
0.265
Exponential is preferred to beta-Poisson; cannot reject good fit for exponential.

 

Optimized k parameter for the exponential model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
k 2.96E-04 2.40E-17 2.40E-17 2.40E-17 7.19E-04 7.19E-04 1.02E-03
ID50/LD50/ETC* 2.34E+03 6.77E+02 9.64E+02 9.64E+02 2.89E+16 2.89E+16 2.89E+16
*Not a parameter of the exponential model; however, it facilitates comparison with other models.

 

Parameter histogram for exponential model (uncertainty of the parameter)

Exponential model plot, with confidence bounds around optimized model

# of Doses
3.00
Μodel
exponential
LD50/ID50
2.34E+03
Dose Units
PFU
Response
infection
Exposure Route
oral
Contains Preferred Model
k
2.96E-04
Agent Strain
porcine, PE3-ECPO-6
Experiment ID
62
Host type
pig
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