intraperitoneal

LD50/ID50

4.23E+08

Dose Units

Response

Exposure Route

Contains Preferred Model

Status

fitted

Read more about Elizabethkingia spp3

1.64E-09

Agent Strain

E. anopheles

Experiment ID

ek_ intraperitoneal2

Experiment Dataset

Description

Host

Spiny Frogs

# of Doses

4.00

Μodel

N50

4.23E+08 (β = 137,348)

LD50/ID50

4.23E+08

Dose Units

Response

Exposure Route

Contains Preferred Model

Status

fitted

Read more about Elizabethkingia spp2

0.72

Agent Strain

E. miricola

Experiment ID

ek_intraperitoneal

Experiment Dataset

Description

**Mouse/ CO92 model data**
Dose	Dead	Survived	Total
2	0	20	20
8	5	15	20
26	13	7	20
74	9	1	10
257	10	0	10

**Goodness of fit and model selection**
Model	Deviance	Δ	Degrees of freedom	χ²_0.95,1 p-value	χ²_0.95,m-k p-value
Exponential	3.12	-9.43e-05	4	3.84 1	9.49 0.539
Beta Poisson	3.12	-9.43e-05	3	3.84 1	7.81 0.374
Exponential is preferred to beta-Poisson; cannot reject good fit for exponential.

**Optimized k parameter for the exponential model, from 10000 bootstrap iterations**
Parameter	MLE estimate	Percentiles
Parameter	MLE estimate	0.5%	2.5%	5%	95%	97.5%	99.5%
k	3.45E-02	2.01E-02	2.28E-02	2.44E-02	4.89E-02	5.18E-02	5.79E-02
ID50/LD50/ETC*	2.01E+01	1.20E+01	1.34E+01	1.42E+01	2.84E+01	3.04E+01	3.44E+01
*Not a parameter of the exponential model; however, it facilitates comparison with other models.

Parameter histogram for exponential model (uncertainty of the parameter)

Exponential model plot, with confidence bounds around optimized model

# of Doses

5.00

Μodel

LD50/ID50

2.01E+01

Dose Units

Response

Exposure Route

Contains Preferred Model

Read more about Optimization Output for Exp. 3

3.45E-02

Agent Strain

CO92

Experiment ID

Host type

Description

**Mice/phase I Ohio strain model data**
Dose	Dead	Survived	Total
0.7	0	30	30
7	0	20	20
70	0	30	30
7000	0	30	30
7E+05	0	30	30
7E+06	1	19	20
7E+07	6	24	30
7E+08	16	14	30
7E+09	23	7	30
7E+10	19	1	20

**Goodness of fit and model selection**
Model	Deviance	Δ	Degrees of freedom	χ²_0.95,1 p-value	χ²_0.95,m-k p-value
Exponential	73.9	72.8	9	3.84 0	16.9 2.65e-12
Beta Poisson	1.11	72.8	8	3.84 0	15.5 0.997
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

**Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations**
Parameter	MLE estimate	Percentiles
Parameter	MLE estimate	0.5%	2.5%	5%	95%	97.5%	99.5%
α	3.57E-01	1.91E-01	2.20E-01	2.38E-01	6.34E-01	7.08E-01	9.84E-01
N₅₀	4.93E+08	1.89E+08	2.41E+08	2.73E+08	9.34E+08	1.06E+09	1.36E+09

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

beta Poisson model plot, with confidence bounds around optimized model

# of Doses

10.00

Μodel

N50

4.93E+08

LD50/ID50

4.93E+08

Dose Units

PFU

Response

Exposure Route

Contains Preferred Model

Read more about Optimization Output for Exp. 28

3.57E-01

Agent Strain

phase I Ohio

Experiment ID

Host type

C57BL/1OScN mice

Description

**Mice/Nine mile phase I model data**
Dose	Dead	Survived	Total
0.05	0	10	10
0.5	0	10	10
5	0	10	10
50	0	10	10
501	0	10	10
5010	0	10	10
50100	0	10	10
501000	0	10	10
5010000	0	10	10
5.01E+07	0	10	10
5.01E+08	1	9	10
5.01E+09	3	7	10
5.01E+10	9	1	10

**Goodness of fit and model selection**
Model	Deviance	Δ	Degrees of freedom	χ²_0.95,1 p-value	χ²_0.95,m-k p-value
Exponential	1.63	0.936	12	3.84 0.333	21 1
Beta Poisson	0.693	0.936	11	3.84 0.333	19.7 1
Exponential is preferred to beta-Poisson; cannot reject good fit for exponential.

**Optimized k parameter for the exponential model, from 10000 bootstrap iterations**
Parameter	MLE estimate	Percentiles
Parameter	MLE estimate	0.5%	2.5%	5%	95%	97.5%	99.5%
k	5.7E-11	2.31E-11	2.94E-11	3.33E-11	1.38E-10	1.61E-10	2.13E-10
ID50/LD50/ETC*	1.22E+10	3.25E+09	4.30E+09	5.02E+09	2.08E+10	2.36E+10	2.99E+10
*Not a parameter of the exponential model; however, it facilitates comparison with other models.

Parameter histogram for exponential model (uncertainty of the parameter)

Exponential model plot, with confidence bounds around optimized model

# of Doses

13.00

Μodel

LD50/ID50

1.22E+10

Dose Units

PFU

Response

Exposure Route

Contains Preferred Model

Read more about Optimization Output for Exp. 26

5.7E-11

Agent Strain

Nine mile phase I

Experiment ID

Host type

C57BL/6 mice

Description

**mice/ scrapie strain C506M3 model data**
Dose	Dead	Survived	Total
125	0	11	11
1250	1	9	10
12500	2	8	10

**Goodness of fit and model selection**
Model	Deviance	Δ	Degrees of freedom	χ²_0.95,1 p-value	χ²_0.95,m-k p-value
Exponential	1.34	0.99	2	3.84 0.32	5.99 0.512
Beta Poisson	0.35	0.99	1	3.84 0.32	3.84 0.554
Exponential is preferred to beta-Poisson; cannot reject good fit for exponential.

**Optimized k parameter for the exponential model, from 10000 bootstrap iterations**
Parameter	MLE estimate	Percentiles
Parameter	MLE estimate	0.5%	2.5%	5%	95%	97.5%	99.5%
k	2.4E-05	1.00E-13	1.00E-13	7.23E-06	5.47E-05	5.81E-05	7.44E-05
ID50/LD50/ETC*	2.89E+04	9.32E+03	1.19E+04	1.27E+04	9.58E+04	6.92E+12	6.92E+12
*Not a parameter of the exponential model; however, it facilitates comparison with other models.

Parameter histogram for exponential model (uncertainty of the parameter)

Exponential model plot, with confidence bounds around optimized model

# of Doses

3.00

Μodel

LD50/ID50

2.89E+04

Dose Units

LD50 i.c.

Response

Exposure Route

Contains Preferred Model

Read more about Optimization Output for Exp. 251

2.4E-05

Agent Strain

scrapie strain C506M3

Experiment ID

251

Host type

Description

**Mice/ Salmonella strain 533 data**
Dose	Dead	Survived	Total
1E+04	20	180	200
1E+05	17	153	170
1E+06	11	29	40
3160000	6	24	30
1E+07	12	8	20
3.16E+07	17	3	20
1E+08	19	1	20

**Goodness of fit and model selection**
Model	Deviance	Δ	Degrees of freedom	χ²_0.95,1 p-value	χ²_0.95,m-k p-value
Exponential	214	165	6	3.84 0	12.6 0
Beta Poisson	48.7	165	5	3.84 0	11.1 2.56e-09
Neither the exponential nor beta-Poisson fits well; beta-Poisson is less bad.

**Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations**
Parameter	MLE estimate	Percentiles
Parameter	MLE estimate	0.5%	2.5%	5%	95%	97.5%	99.5%
α	1.08E-01	6.19E-02	7.06E-02	7.52E-02	1.79E-01	1.98E-01	2.44E-01
N₅₀	9.66E+06	1.93E+06	2.43E+06	2.82E+06	5.38E+07	8.11E+07	2.13E+08

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

beta Poisson model plot, with confidence bounds around optimized model

# of Doses

7.00

Μodel

N50

9.66E+06

LD50/ID50

9.66E+06

Dose Units

Response

Exposure Route

Contains Preferred Model

Read more about Optimization Output for Exp. 248

1.08E-01

Agent Strain

strain 533

Experiment ID

248

Host type

Description

**Mice/ Salmonella strain 533 data**
Dose	Dead	Survived	Total
603	6	36	42
1910	3	39	42
6030	7	35	42
19100	5	42	47
60300	6	34	40
191000	3	29	32
603000	6	20	26
1910000	7	7	14
6030000	7	5	12
1.91E+07	10	2	12
6.03E+07	13	0	13

**Goodness of fit and model selection**
Model	Deviance	Δ	Degrees of freedom	χ²_0.95,1 p-value	χ²_0.95,m-k p-value
Exponential	193	146	10	3.84 0	18.3 0
Beta Poisson	47.5	146	9	3.84 0	16.9 3.22e-07
Neither the exponential nor beta-Poisson fits well; beta-Poisson is less bad.

**Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations**
Parameter	MLE estimate	Percentiles
Parameter	MLE estimate	0.5%	2.5%	5%	95%	97.5%	99.5%
α	6.21E-02	3.53E-02	4.06E-02	4.32E-02	1.09E-01	1.25E-01	1.80E-01
N₅₀	3.46E+07	9.76E+05	1.69E+06	2.40E+06	9.41E+08	2.13E+09	1.34E+10

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

beta Poisson model plot, with confidence bounds around optimized model

# of Doses

11.00

Μodel

N50

3.46E+07

LD50/ID50

3.46E+07

Dose Units

Response

Exposure Route

Contains Preferred Model

Read more about Optimization Output for Exp. 247

6.21E-02

Agent Strain

strain 533

Experiment ID

247

Host type