Description
Mice/Naegleria fowleri LEE strain data
Dose Dead Survived Total
1E+03 7 3 10
1E+04 8 2 10
1E+05 10 0 10
1E+06 10 0 10

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom

χ20.95,1

 

 χ20.95,m-k 
 
Exponential 11.28 9.64 3 3.84 7.81 
0.325
Beta Poisson 1.64 2 5.99 
0.177
Beta-Poisson is preferred to Exponential;
Beta-Poisson model plot
Beta-Poisson model plot
# of Doses
4.00
Μodel
beta-Poisson
N50
422
LD50/ID50
422
Dose Units
no of trophozoites
Response
death
Exposure Route
intranasal
Contains Preferred Model
Status
fitted
a
0.536
Experiment ID
954
Host type
A/J mice
Experiment Dataset
Description
Mice/MHV-1 strains model data [3]
Dose Dead Survived Total
5 0 5 5
50 1 4 5
500 3 2 5
5000 5 0 5

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 0.606 0.0689 3 3.84 
0.793 		7.81 
0.895
Beta Poisson 0.537 2 5.99 
0.765
Exponential is preferred to beta-Poisson; cannot reject good fit for exponential.

 

Optimized k parameter for the exponential model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
k 2.14E-03 6.25E-04 6.55E-04 9.06E-04 6.58E-03 6.58E-03 9.86E-03
ID50/LD50/ETC* 3.24E+02 7.03E+01 1.05E+02 1.05E+02 7.65E+02 1.06E+03 1.11E+03
*Not a parameter of the exponential model; however, it facilitates comparison with other models.

 

Parameter histogram for exponential model (uncertainty of the parameter)

Exponential model plot, with confidence bounds around optimized model

# of Doses
4.00
Μodel
exponential
LD50/ID50
3.24E+02
Dose Units
PFU
Response
death
Exposure Route
intranasal
Contains Preferred Model
k
2.14E-03
Agent Strain
MHV-1
Experiment ID
261
Host type
A/J mice
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