Listeria monocytogenes (Death as response): Dose Response Models
General Overview
Listeria monocytogenes is a Gram-positive rod-shaped bacterium. It is the causative agent of listeriosis, a serious infection caused by eating food contaminated with the bacteria. The disease generally affects older adults, pregnant women, newborns, and adults with weakened immune systems.
ID | Exposure Route | # of Doses | Agent Strain | Dose Units | Host type | Μodel | LD50/ID50 | Optimized parameters | Response type | Reference |
---|---|---|---|---|---|---|---|---|---|---|
292 | oral | 6.00 | F5817 | CFU | beta-Poisson | a = 0.253 N50 = 277 | infection |
Model | Deviance | Δ | Degrees of freedom |
χ20.95,1 p-value |
χ20.95,m-k p-value |
Exponential | 9.88 | 6.48 | 5 | 3.84 0.011 |
11.1 0.0788 |
beta Poisson | 3.4 | 4 | 9.49 0.494 |
||
beta-Poisson fits better than exponential; can not reject good fit for beta-Poisson |
Parameter | MLE Estimate | 0.5% | 2.5% | 5% | 95% | 97.5% | 99.5% |
α | 6.95E-01 | 2.69E-01 | 3.39E-01 | 3.78E-01 | 2.56E+0 | 2.28E+01 | 1.18E+03 |
N50 | 3.39E+03 | 3.58E+01 | 2.47E+02 | 4.67E+02 | 1.09E+04 | 1.26E+04 | 1.85E+04 |