Description
Mice/Naegleria fowleri LEE strain data
Dose Dead Survived Total
1E+02 0 10 10
1E+03 0 10 10
1E+04 1 9 10
1E+05 4 6 10
1E+05 7 3 10

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom

χ20.95,1

 

 χ20.95,m-k 
 
Exponential 6.13 5.88 4 3.84  9.49
Beta Poisson 0.25 3  7.81
Beta-Poisson is preferred to Exponential;
Beta-Poisson model plot with confidence bounds around optimized model
Beta-Poisson model plot with confidence bounds around optimized model
Host
CD1 Mice
# of Doses
5.00
Μodel
beta-Poisson
N50
1.99E+05
LD50/ID50
1.99E+05
Dose Units
no of trophozoites
Response
death
Exposure Route
Swimming 5 minutes
Contains Preferred Model
Status
fitted
a
0.353
Agent Strain
LEE
Experiment ID
955
Experiment Dataset
Description
Mice/Naegleria fowleri LEE strain data
Dose Dead Survived Total
1E+03 7 3 10
1E+04 8 2 10
1E+05 10 0 10
1E+06 10 0 10

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom

χ20.95,1

 

 χ20.95,m-k 
 
Exponential 11.28 9.64 3 3.84 7.81 
0.325
Beta Poisson 1.64 2 5.99 
0.177
Beta-Poisson is preferred to Exponential;
Beta-Poisson model plot
Beta-Poisson model plot
# of Doses
4.00
Μodel
beta-Poisson
N50
422
LD50/ID50
422
Dose Units
no of trophozoites
Response
death
Exposure Route
intranasal
Contains Preferred Model
Status
fitted
a
0.536
Experiment ID
954
Host type
A/J mice
Experiment Dataset
Lead Editor: 
Sushil Tamrakar
Description
myco
 
Host
Male golden Syrian hamsters/12 weeks
# of Doses
3.00
Μodel
beta-Poisson
N50
7.93E+8
LD50/ID50
7.93E+8
Dose Units
CFU
Response
Liver infection
Exposure Route
Intratracheal inoculation
Contains Preferred Model
Status
fitted
a
0.048
Agent Strain
MAC serotype 8 (Human-derived, AIDS Patient)
Experiment ID
myco_intratracheal_2
Host type
hamsters
Experiment Dataset
Description
myco
Host
Male golden Syrian hamsters/12 weeks
# of Doses
3.00
Μodel
beta-Poisson
N50
1.42E+8
LD50/ID50
1.42E+8
Dose Units
CFU
Response
Disseminated infection
Exposure Route
Intratracheal inoculation
Contains Preferred Model
Status
fitted
a
0.201
k
4.87E-9
Agent Strain
MAC serotype 8 (Human-derived, AIDS Patient)
Experiment ID
myco_intratracheal
Host type
hamsters
Experiment Dataset
Description
 
Host
Pig/ 8-10 weeks old
# of Doses
15.00
Μodel
exponential
LD50/ID50
4.19E+7
Dose Units
CFU
Response
Lesions or culture in lymph nodes
Exposure Route
intravenous
Contains Preferred Model
Status
fitted
k
1.65E-8
Experiment ID
myco_intravenous_4
Host type
pig
Description
Host
Pig/ 8-10 weeks old
# of Doses
15.00
Μodel
exponential
LD50/ID50
8.79E+6
Dose Units
CFU
Response
Lesions or culture in lymph nodes
Exposure Route
intravenous
Contains Preferred Model
Status
fitted
k
7.88E-8
Agent Strain
M. avium serotype II strain SSC 1323 (porcine-derived)
Experiment ID
myco_intravenous_3
Host type
pig
Description
myco_3.png
Host
Pig/ 8-10 weeks old
# of Doses
15.00
Μodel
exponential
LD50/ID50
7.49E+7
Dose Units
CFU
Response
Lesions or culture in lymph nodes
Exposure Route
intravenous
Contains Preferred Model
Status
fitted
k
9.26E-9
Agent Strain
M. avium serotype II strain SSC 1323 (porcine-derived
Experiment ID
myco_intravenous_3
Host type
pig
Experiment Dataset
Description
myco
Host
C57BL/6 beige mice/NS
# of Doses
5.00
Μodel
exponential
LD50/ID50
2.22E+8
Dose Units
CFU
Response
death
Exposure Route
intravenous
Contains Preferred Model
Status
fitted
k
3.12E-9
Agent Strain
MAC 101 (human-derived)
Experiment ID
myco_intravenous_2
Host type
mice
Experiment Dataset
Description
Mycobacterium_Avium_1
Host
Female C57BL/6 beige Mice/5 weeks
# of Doses
5.00
Μodel
exponential
LD50/ID50
6.30E+5
Dose Units
CFU
Response
Lung lesions
Exposure Route
intravenous
Contains Preferred Model
Status
fitted
k
1.10E-6
Agent Strain
M. avium serovar 1, human non- AIDS isolates: pooled strains N-289, N-356, N-357, N-364, N-445, N458, N-461; Serovar 9 strains N-254, N-302
Experiment ID
myco_intravenous
Host type
mice
Experiment Dataset
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