Description
EPEC disease in the human model data
Dose Diarrhea No diarrhea Total
1E+06 0 4 4
1E+06 1 4 5
1E+08 1 4 5
5E+08 3 2 5
2.5E+09 6 0 6
1E+10 3 2 5
1E+10 5 0 5
2E+10 2 0 2

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 31.8 20.6 7 3.84 
5.69e-06 		14.1 
4.37e-05
Beta Poisson 11.2 6 12.6 
0.0813
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 2.21E-01 9.31E-02 1.18E-01 1.27E-01 1.25E+00 7.41E+02 1.29E+04
N50 6.85E+07 6.14E+06 1.11E+07 1.52E+07 6.32E+08 7.69E+08 1.09E+09
Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.
Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.
beta Poisson model plot, with confidence bounds around optimized model
beta Poisson model plot, with confidence bounds around optimized model
# of Doses
8.00
Μodel
beta-Poisson
N50
6.85E+07
LD50/ID50
6.85E+07
Dose Units
CFU
Response
diarrhea
Exposure Route
oral (with NaHCO3)
Contains Preferred Model
a
2.21E-01
Agent Strain
EPEC B171-8 (serotype O11:NM)
Experiment ID
214, 216, 217
Host type
human
Experiment Dataset
Description
Pooled data of guinea pig and diabetic rat  
Dose DEATH NOT DEATH Total
44 1 4 5
440 3 2 5
3000 6 4 10
4400 4 1 5
3E+04 7 3 10
44000 5 0 5
3E+05 7 3 10
440000 5 0 5
3E+06 10 0 10
4.4E+06 4 1 5
3E+07 10 0 10

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 163 152 10 3.84 
0 		18.3 
0
Beta Poisson 10.1 9 16.9 
0.343
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 2.13E-01 9.14E-02 1.26E-01 1.39E-01 3.38E-01 3.76E-01 5.60E-01
N50 4.77E+02 3.04E+00 1.63E+01 7.19E+01 2.16E+03 2.75E+03 4.44E+03
Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.
Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

 

beta Poisson model plot, with confidence bounds around optimized model
beta Poisson model plot, with confidence bounds around optimized model
# of Doses
11.00
Μodel
beta-Poisson
N50
4.77E+02
LD50/ID50
4.77E+02
Dose Units
CFU
Response
death
Exposure Route
intraperitoneal
Contains Preferred Model
a
2.13E-01
Agent Strain
W294, 316c
Experiment ID
21,23
Host type
guinea pig and diabetic rat
Experiment Dataset
Description
Guinea Pigs W294 Strain Data 
Dose Dead Survived Total
44 1 4 5
440 3 2 5
4400 4 1 5
44000 5 0 5
440000 5 0 5
4.4E+06 4 1 5

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 70.3 66.1 5 3.84 
4.44e-16 		11.1 
8.93e-14
Beta Poisson 4.14 4 9.49 
0.387
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 2.67E-01 3.36E-02 8.80E-02 1.16E-01 1.05E+01 3.45E+02 3.55E+03
N50 2.55E+02 4.80E-07 2.49E+00 1.48E+01 1.35E+03 1.80E+03 3.22E+03
Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.
Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.
beta Poisson model plot, with confidence bounds around optimized model
beta Poisson model plot, with confidence bounds around optimized model
# of Doses
6.00
Μodel
beta-Poisson
N50
2.55E+02
LD50/ID50
2.55E+02
Dose Units
CFU
Response
death
Exposure Route
intraperitoneal
Contains Preferred Model
a
2.67E-01
Agent Strain
W294
Experiment ID
21
Host type
guinea pig
Experiment Dataset
Description
Mouse/ KIM D27 model data 
Dose Dead Survived Total
100 0 10 10
1000 2 8 10
1E+04 6 4 10
1E+05 10 0 10

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 1.21 0.138 3 3.84 
0.711 		7.81 
0.75
Beta Poisson 1.07 2 5.99 
0.585
Exponential is preferred to beta-Poisson; cannot reject good fit for exponential.

 

Optimized k parameter for the exponential model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
k 1.07E-04 3.85E-05 4.70E-05 5.57E-05 1.93E-04 2.22E-04 3.29E-04
ID50/LD50/ETC* 6.47E+03 2.11E+03 3.12E+03 3.59E+03 1.24E+04 1.48E+04 1.80E+04
*Not a parameter of the exponential model; however, it facilitates comparison with other models.

 

Parameter histogram for exponential model (uncertainty of the parameter)

Exponential model plot, with confidence bounds around optimized model

# of Doses
4.00
Μodel
exponential
LD50/ID50
6.47E+03
Dose Units
CFU
Response
death
Exposure Route
intranasal
Contains Preferred Model
k
1.07E-04
Agent Strain
KIM D27
Experiment ID
2
Host type
mice
Description
Moredunn isolate data 
Dose Infected Non-infected Total
100 2 2 4
300 2 3 5
1000 1 2 3
3000 3 1 4

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 7.37 6.16 3 3.84 
0.0131 		7.81 
0.0611
Beta Poisson 1.21 2 5.99 
0.546
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 1.14E-01 9.79E-04 9.81E-04 9.82E-04 1.17E+03 2.25E+03 5.52E+03
N50 4.55E+02 2.13E-09 2.19E-06 1.55E-05 5.62E+05 3.59E+09 1.43E+16

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

beta Poisson model plot, with confidence bounds around optimized model.

# of Doses
4.00
Μodel
beta-Poisson
N50
4.55E+02
LD50/ID50
4.55E+02
Dose Units
oocysts
Response
infection
Exposure Route
oral
Contains Preferred Model
a
1.14E-01
Agent Strain
Moredun isolate
Experiment ID
183
Host type
human
Description
TU502 data 
Dose Diarrhea Not diarrhea Total
10 2 3 5
30 3 2 5
100 5 2 7
500 3 1 4

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 11.6 11.5 3 3.84 
0.000708 		7.81 
0.00894
Beta Poisson 0.119 2 5.99 
0.942
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 2.7E-01 9.83E-04 9.85E-04 2.03E-03 6.60E+00 6.70E+02 3.19E+03
N50 1.68E+01 3.41E-16 9.86E-09 1.68E-06 7.15E+01 9.76E+01 6.59E+02

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

beta Poisson model plot, with confidence bounds around optimized model.

# of Doses
4.00
Μodel
beta-Poisson
N50
1.68E+01
LD50/ID50
1.68E+01
Dose Units
oocysts
Response
diarrhea
Exposure Route
oral
Contains Preferred Model
a
2.7E-01
Agent Strain
*C. hominis*, TU502
Experiment ID
181
Host type
human
Description

Optimization Output for experiment 18 and 23 pooled (B. pseudomallei)

Pooled data of C57BL/6 mice and diabetic rat 
Dose DEATH NOT DEATH Total
150 0 6 6
450 1 5 6
1350 1 5 6
3000 6 4 10
4050 3 3 6
12200 3 3 6
3E+04 7 3 10
3E+05 7 3 10
3E+06 10 0 10
3E+07 10 0 10

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 63.3 56.6 9 3.84 
5.42e-14 		16.9 
3.15e-10
Beta Poisson 6.68 8 15.5 
0.571
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 3.28E-01 1.94E-01 2.16E-01 2.31E-01 5.15E-01 5.86E-01 8.32E-01
N50 5.43E+03 1.82E+03 2.37E+03 2.64E+03 1.23E+04 1.39E+04 1.68E+04
Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.
Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

 

beta Poisson model plot, with confidence bounds around optimized model
beta Poisson model plot, with confidence bounds around optimized model

 

# of Doses
10.00
Μodel
beta-Poisson
N50
5.43E+03
LD50/ID50
5.43E+03
Dose Units
CFU
Response
death
Contains Preferred Model
a
3.28E-01
Agent Strain
KHW,316c
Experiment ID
18,23
Host type
C57BL/6 mice and diabetic rat
Experiment Dataset
Description
C57BL/6 Mice KHW Strain Data 
Dose Infected Non-infected Total
150 0 6 6
450 1 5 6
1350 1 5 6
4050 3 3 6
12200 3 3 6

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 3.36 2.17 4 3.84 
0.141 		9.49 
0.499
Beta Poisson 1.19 3 7.81 
0.755
Exponential is preferred to beta-Poisson; cannot reject good fit for exponential.

 

Optimized parameters for the exponential model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
k 1E-04 2.87E-05 4.15E-05 4.99E-05 1.89E-04 2.13E-04 2.70E-04
ID50/LD50/ETC* 6.92E+03 2.57E+03 3.26E+03 3.68E+03 1.39E+04 1.67E+04 2.41E+04
*Not a parameter of the exponential model; however, it facilitates comparison with other models.
Parameter histogram for exponential model (uncertainty of the parameter)
Parameter histogram for exponential model (uncertainty of the parameter)
Exponential model plot, with confidence bounds around optimized model
Exponential model plot, with confidence bounds around optimized model
# of Doses
5.00
Μodel
exponential
LD50/ID50
6.92E+03
Dose Units
CFU
Response
infection
Exposure Route
intranasal
Contains Preferred Model
k
1.00E-04
Agent Strain
KHW
Experiment ID
18
Host type
C57BL/6 mice
Experiment Dataset
Description
BALB/c Mice KHW Strain Data 
Dose Infected Non-infected Total
5 0 6 6
15 0 6 6
45 3 1 4
135 4 2 6
405 6 0 6

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 5.25 -0.000362 4 3.84 
1 		9.49 
0.263
Beta Poisson 5.25 3 7.81 
0.154
Exponential is preferred to beta-Poisson; cannot reject good fit for exponential.

 

Optimized parameters for the exponential model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
k 1.04E-02 4.94E-03 5.96E-03 6.60E-03 1.92E-02 2.45E-02 2.45E-02
ID50/LD50/ETC* 6.63E+01 2.82E+01 2.82E+01 3.61E+01 1.05E+02 1.16E+02 1.40E+02
*Not a parameter of the exponential model; however, it facilitates comparison with other models.
Parameter histogram for exponential model (uncertainty of the parameter)
Parameter histogram for exponential model (uncertainty of the parameter)

 

Exponential model plot, with confidence bounds around optimized model
Exponential model plot, with confidence bounds around optimized model

 

 

 

# of Doses
5.00
Μodel
exponential
LD50/ID50
6.63E+01
Dose Units
CFU
Response
infection
Exposure Route
intranasal
Contains Preferred Model
k
1.04E-02
Agent Strain
KHW
Experiment ID
17
Host type
BALB/c mice
Experiment Dataset
Description
Human Inaba 569B 
Dose Diarrhea and culture positive No diarrhea and culture positive Total
1E+04 0 2 2
1E+06 0 4 4
1E+07 0 4 4
1E+08 2 2 4
1E+09 0 2 2
1E+10 0 1 1
1E+11 2 0 2

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 14.9 7.58 6 3.84 
0.00589 		12.6 
0.0207
Beta Poisson 7.36 5 11.1 
0.195
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 1.31E-01 1.04E-03 1.04E-03 1.04E-03 1.67E-01 1.67E-01 1.67E-01
N50 2.91E+09 3.23E+08 3.23E+08 3.23E+08 8.87E+254 8.87E+254 8.87E+254

 

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

beta Poisson model plot, with confidence bounds around optimized model

# of Doses
7.00
Μodel
beta-Poisson
N50
2.91E+09
LD50/ID50
2.91E+09
Dose Units
CFU
Response
diarrhea and culture positive
Exposure Route
oral (no NaHCO3)
Contains Preferred Model
a
1.31E-01
Agent Strain
Inaba 569B (classical)
Experiment ID
167
Host type
human
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